Donatello has slower attacks but a longer range, Michelangelo and Raphael have faster attacks but a shorter range, and Leonardo is a well-rounded Turtle with average range and speed. Up to four players (two in some versions) can take control of any of the Turtles. After Shredder kidnaps the Turtles' friend April O'Neil and their mentor Splinter, they must give chase, save their comrades, and defeat the evil Shredder.

Depending on the version of the game, the characters are either chosen via an in-game select screen or based on which coin slot the player placed their credit into. The player chooses from one of the four Ninja Turtles: Leonardo, Michelangelo, Donatello, and Raphael. A sequel, Teenage Mutant Ninja Turtles: Turtles in Time, was released in 1991. Versions for various home systems soon followed, including the Nintendo Entertainment System. Released during a high point in popularity for the Teenage Mutant Ninja Turtles franchise, the arcade game was a worldwide hit, becoming the highest-grossing dedicated arcade game of 1990 in the United States and Konami's highest-grossing arcade game. In the game, up to four players control the titular Ninja Turtles, fighting through various levels to defeat the turtles' enemies, including the Shredder, Krang and the Foot Clan. It is based on the Teenage Mutant Ninja Turtles franchise, including the first animated series that began airing two years earlier.

Teenage Mutant Ninja Turtles, released in Japan as TMNT: Super Kame Ninja and in Europe as Teenage Mutant Hero Turtles, is a 1989 beat 'em up arcade game released by Konami.

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